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Impact of Major Bleeding on 30-Day Mortality and Clinical Outcomes in Patients With Acute Coronary Syndromes

An Analysis From the ACUITY Trial

Steven V. Manoukian, MD, FACC^_*,_*, Frederick Feit, MD, FACC, Roxana Mehran, MD, FACC, Michele D. Voeltz, MD^_*, Ramin Ebrahimi, MD, FACC, Martial Hamon, MD^||, George D. Dangas, MD, PhD, FACC, A. Michael Lincoff, MD, FACC^¶, Harvey D. White, DSc, FACC^#, Jeffrey W. Moses, MD, FACC, Spencer B. King, III, MD, MACC^_**, E. Magnus Ohman, MD, FACC and Gregg W. Stone, MD, FACC

^_* Department of Medicine, Emory University School of Medicine, Atlanta, Georgia
^_** Fuqua Heart Center, Atlanta, Georgia
Department of Medicine, New York University School of Medicine, New York, New York
Department of Medicine, Columbia University Medical Center and the Cardiovascular Research Foundation, New York, New York
Department of Medicine, University of California Los Angeles, Los Angeles, California
^|| Service des Maladies du Cur et des Vaisseaux, Centre Hospitalier Universitaire de Caen, Caen, France
^¶ Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio
^# Green Lane Cardiovascular Service, Auckland City Hospital, Auckland, New Zealand
Department of Medicine, Duke University School of Medicine, Durham, North Carolina.

View larger version (19K): [in this window] [in a new window] [Download PPT slide]   Figure 1 Independent Predictors of Major Bleeding *Anemia was defined as baseline hemoglobin <13 g/dl in men and <12 g/dl in women. Renal insufficiency was defined as a creatinine clearance <60 ml/min as calculated by the Cockcroft-Gault equation. Unfractionated heparin or enoxaparin. CI = confidence interval; GPI = glycoprotein IIb/IIIa inhibitor; OR = odds ratio; PCI = percutaneous coronary intervention.

View larger version (21K): [in this window] [in a new window] [Download PPT slide]   Figure 2 Kaplan-Meier Curves for Mortality

View larger version (21K): [in this window] [in a new window] [Download PPT slide]   Figure 3 Independent Predictors of Mortality CABG = coronary artery bypass surgery; other abbreviations as in Figure 1.