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J Am Coll Cardiol, 2007; 49:1175-1177, doi:10.1016/j.jacc.2006.12.022 (Published online 5 March 2007).
© 2007 by the American College of Cardiology Foundation
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Ventricular Unloading, Tissue Angiotensin II, Matrix Modulation, and Function During Left Ventricular Assist Device Support*

Bodh I. Jugdutt, MBChB, MSc, MD, FRCPC, FACC{dagger},{ddagger},* and Craig Butler, MSc, MD, FRCPC{dagger}

{dagger} Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, Canada
{ddagger} Cardiovascular Research Group, University of Alberta, Edmonton, Canada.


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  		Figure 1 Potential Therapeutic Adjuncts for LVAD Support in End-Stage Heart Failure

AA = angiotensin-aldosterone; ACE-Is = angiotensin-converting enzyme inhibitors; AngII = angiotensin II; ARB = angiotensin receptor blocker; ECCM = extracellular collagen matrix; HGF = hepatocyte growth factor; IGF = insulin-like growth factor; LVAD = left ventricular assist device; LV = left ventricular; MMP = matrix metalloproteinase; RAAS = renin-angiotensin-aldosterone system; TIMP = tissue inhibitor of MMP; VEGF = vascular endothelial growth factor.

 




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