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J Am Coll Cardiol, 2007; 49:1027-1034, doi:10.1016/j.jacc.2006.10.067 (Published online 25 February 2007).
© 2007 by the American College of Cardiology Foundation
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Long-Term Safety of a Novel Antianginal Agent in Patients With Severe Chronic Stable Angina

The Ranolazine Open Label Experience (ROLE)

Michael J. Koren, MD, FACC*,*, Michael R. Crager, PhD{dagger} and Michael Sweeney, MD{dagger}

* Jacksonville Center for Clinical Research, Jacksonville, Florida
{dagger} CV Therapeutics, Inc., Palo Alto, California.


Figure 1
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  		Figure 1 The ROLE Program Schematic

Disposition of subjects in preceding double-blind trials leading to the ROLE (Ranolazine Open Label Experience) program. AE = adverse event; CARISA = Assessment of Ranolazine in Stable Angina trial; MARISA = Monotherapy Assessment of Ranolazine In Stable Angina trial; pts = patients.

 

Figure 2
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  		Figure 2 Survival Time During the ROLE Program and the Original, Randomized Trials MARISA and CARISA

Kaplan-Meier estimate. Abbreviations as in Figure 1.

 




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