Associations Among Androgens, Estrogens, and Natriuretic Peptides in Young Women
Observations From the Dallas Heart Study
Alice Y. Chang, MD4,*,
Shuaib M. Abdullah, MD,
Tulika Jain, MD,
Harold G. Stanek, MS,
Sandeep R. Das, MD, MPH,
Darren K. McGuire, MD, MHSc3,
Richard J. Auchus, MD, PhD2 and
James A. de Lemos, MD1
The Donald W. Reynolds Cardiovascular Clinical Research Center and the Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.
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Figure 1 Overview of Reynolds Women’s Study and Subject Selection for Current Analysis
BMI = body mass index; DEXA = dual energy X-ray absorbtiometry; DHS = Dallas Heart Study; MRI = magnetic resonance imaging.
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Figure 2 Algorithm for Determining Menopausal Status in the Dallas Heart Study
See text for details. The group distributions are pre-menopausal women, n = 939; post-menopausal, n = 692; and unclear hormonal status, n = 340. BSO = bilateral salpingo-oophorectomy; FSH = follicle-stimulating hormone; LMP = last menstrual period; PCOS = polycystic ovarian syndrome.
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Figure 3 Association Between Natriuretic Peptides, Calculated Free Testosterone, and Sex Hormone-Binding Globulin
Data points represent median (25th and 75th percentiles) for each quartile of each variable. BNP = B-type natriuretic peptide; cFT = calculated free testosterone; NT-proBNP = N-terminal pro-B-type natriuretic peptide; SHBG = sex hormone-binding globulin.
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