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J Am Coll Cardiol, 2006; 48:24-32, doi:10.1016/j.jacc.2006.04.097 (Published online 16 October 2006).
© 2006 by the American College of Cardiology Foundation
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Peroxisome Proliferator-Activated Receptors at the Crossroads of Obesity, Diabetes, and Cardiovascular Disease

Andries J. Gilde, PhD*,{dagger}, Jean-Charles Fruchart, PhD*,{dagger},{ddagger} and Bart Staels, PhD*,{dagger},{ddagger},*

* INSERM U545, Institut Pasteur de Lille, France
{dagger} Department of Atherosclerosis, Institut Pasteur de Lille, France
{ddagger} University of Lille 2, Lille, France.


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  		Figure 1 Schematic representation of the transcriptional action of peroxisome proliferator-activated receptors (PPARs) with their heterodimer partner retinoic X receptor (RXR) and their major physiological functions. *Major function for this isoform but not exclusive. L = ligand; PPRE = peroxisome proliferator-activated receptor-responsive element.

 




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