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J Am Coll Cardiol, 2006; 48:10-14, doi:10.1016/j.jacc.2006.06.046 (Published online 16 October 2006).
© 2006 by the American College of Cardiology Foundation
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Genetic Approaches to Coronary Heart Disease

Jonathan C. Cohen, PhD*

Center for Human Nutrition and McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas.


Figure 1
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  		Figure 1 Multistage design for genome-wide association study. A multistage design with replication allows testing at a nominal significance threshold with elimination of false-positive associations by replication. Validation in an independent population is essential, with a larger sample size at this step to protect against false-negative associations. SNP = single nucleotide polymorphism.

 




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