Genetic Approaches to Coronary Heart Disease
Jonathan C. Cohen, PhD*
Center for Human Nutrition and McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas.

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Figure 1 Multistage design for genome-wide association study. A multistage design with replication allows testing at a nominal significance threshold with elimination of false-positive associations by replication. Validation in an independent population is essential, with a larger sample size at this step to protect against false-negative associations. SNP = single nucleotide polymorphism.
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