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Genetic Approaches to Coronary Heart Disease

Center for Human Nutrition and McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas.

View larger version (30K): [in this window] [in a new window] [Download PPT slide]   Figure 1 Multistage design for genome-wide association study. A multistage design with replication allows testing at a nominal significance threshold with elimination of false-positive associations by replication. Validation in an independent population is essential, with a larger sample size at this step to protect against false-negative associations. SNP = single nucleotide polymorphism.