Adverse Effects of Dopamine on Systemic Hemodynamic Status and Oxygen Transport in Neonates After the Norwood Procedure
Jia Li, MD, PhD,
Gencheng Zhang, MD, PhD,
Helen Holtby, MBBS,
Tilman Humpl, MD,
Christopher A. Caldarone, MD,
Glen S. Van Arsdell, MD and
Andrew N. Redington, MD*
Cardiac Program, the Hospital for Sick Children, Toronto, Ontario, Canada.
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Figure 1 The individual (thin line)
and mean (bold line with closed squares)
changes in systemic hemodynamic condition and oxygen transport before and after termination of dopamine in 13 neonates during the early period after the Norwood procedure. CO = cardiac output; DO
2
= oxygen delivery; ERO
2
= oxygen extraction ratio; VO
2
= oxygen consumption.
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Figure 2 Examples of the on-line measurement of oxygen consumption (VO
2
) in 3 patients shows the rapid and small (A
, Patient 3), moderate (B
, Patient 2), and great (C
, Patient 4) decreases in VO
2
after terminating dopamine at different times after the arrival in the intensive care unit (ICU). Arrows
indicate the time of terminating dopamine. Short bold lines
indicate the 30-min periods for averaging VO
2
measures before and 100 min after terminating dopamine.
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