Assessment of Renal Artery Stenosis Severity by Pressure Gradient Measurements
Bernard De Bruyne, MD, PhD*,*,
Ganesh Manoharan, MD*,
Nico H.J. Pijls, MD, PhD ,
Katia Verhamme, MD, PhD ,
Juraj Madaric, MD*,
Jozef Bartunek, MD, PhD*,
Marc Vanderheyden, MD* and
Guy R. Heyndrickx, MD, PhD*
* Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium
Department of Cardiology, Catharina Hospital, Eindhoven, the Netherlands
Pharmaco-Epidemiology Unit, Department of Medical Informatics, Erasmus MC, Rotterdam, the Netherlands.
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Figure 1 Example of mean pressure tracings obtained simultaneously in the aorta and distal to the artificial renal stenoses induced by incremental balloon inflations. Each degree of stenosis severity was maintained for 10 min. The arrows
indicate the timing of sampling in the aorta and in both renal veins.
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Figure 2 Relationship between the individual values of mean aortic pressure (Pd
) / mean pressure distal to the renal artery stenosis (Pa
) ratios and the corresponding systolic pressure gradients (closed circles)
and mean pressure gradients across the stenosis (open circles)
.
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Figure 3 Effects of a balloon-induced, unilateral, controlled, graded stenosis (expressed as Pd
/Pa
ratio) on plasma renin concentration in the aorta (squares)
, in the vein of the stenotic kidney (closed circles)
, and in the vein of the non-stenotic kidney (open circles)
. BL 1 = baseline before stenting; BL 2 = baseline after stenting; other abbreviations as in Figure 2
.
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