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Non-Invasive Assessment of Endothelial Function

Which Technique?

Ann E. Donald, AVS^_*,3,_*, Marietta Charakida, MD^_*,3, Tim J. Cole, ScD^_*, Peter Friberg, MD, PhD^_*, Phil J. Chowienczyk, FRCP^,1, Sandrine C. Millasseau, PhD^,2, John E. Deanfield, MB, FRCP^_* and Julian P. Halcox, MD, MRCP^_*

^_* Institute of Child Health, University College London, London, United Kingdom
King’s College London, Cardiovascular Division, Department of Clinical Pharmacology, St. Thomas’ Hospital, London, United Kingdom.

View larger version (13K): [in this window] [in a new window] [Download PPT slide]   Figure 1 Study timeline for (A) adults and (B) children. D = diameter; FMD = flow-mediated dilation; GTN = glyceryl trinitrate; PAI = peripheral augmentation index; RI = reflection index.

View larger version (32K): [in this window] [in a new window] [Download PPT slide]   Figure 2 Bland Altman plots for flow-mediated dilation (FMD), pulse wave analysis (PWA), and pulse contour analysis (PCA) (after Salbutamol) in adults (left) and children (right) . The dotted lines represent the 95% confidence intervals.

View larger version (16K): [in this window] [in a new window] [Download PPT slide]   Figure 3 The impact of typhoid vaccination on endothelial-dependent and endothelial-independent function. Data are expressed as mean values ± SE. *p < 0.05. **p < 0.001. GTN% = glyceryl trinitrate-mediated dilation; other abbreviations as in Figure 1 .