This Article Abstract Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via ISI Web of Science (43) Citing Articles via Google Scholar Google Scholar Articles by Engelmann, M. G. Articles by Franz, W.-M. Search for Related Content PubMed PubMed Citation Articles by Engelmann, M. G. Articles by Franz, W.-M. Related Collections Related Article

Autologous Bone Marrow Stem Cell Mobilization Induced by Granulocyte Colony-Stimulating Factor After Subacute ST-Segment Elevation Myocardial Infarction Undergoing Late Revascularization

Final Results From the G-CSF-STEMI (Granulocyte Colony-Stimulating Factor ST-Segment Elevation Myocardial Infarction) Trial

Markus G. Engelmann, MD^_*, Hans D. Theiss, MD^_*, Christine Hennig-Theiss^_*, Armin Huber, MD, Bernd J. Wintersperger, MD, Anja-Eva Werle-Ruedinger, Stefan O. Schoenberg, MD, Gerhard Steinbeck, MD^_* and Wolfgang-M. Franz, MD^_*,_*

^_* Medical Clinic I—Department of Cardiology, Ludwig Maximilians University, Klinikum Grosshadern, Munich, Germany
Department of Clinical Diagnostic Radiology, Ludwig Maximilians University, Klinikum Grosshadern, Munich, Germany

View larger version (24K): [in this window] [in a new window] [Download PPT slide]   Figure 1 Study design. F/U = follow-up; G-CSF = granulocyte colony-stimulating factor; MRI = magnetic resonance imaging; PCI = percutaneous coronary intervention; s.c. = subcutaneously; STEMI = ST-segment elevation myocardial infarction.

View larger version (35K): [in this window] [in a new window] [Download PPT slide]   Figure 2 Flow cytometry analysis of mobilized stem cells at baseline and 5 days after initiation of granulocyte colony-stimulating factor (G-CSF). CD34+ stem cell populations from peripheral blood measured by flow cytometry. (A) Quantitative measurements of CD34+/CD31+, CD34+/133+, and CD34+/CD117+ cells in placebo and G-CSF-treated patients before and at day 5 of treatment. *p < 0.001; **p < 0.001; ***p < 0.001 when compared with placebo at day 5. (B) The R4 population demonstrates increases of precursor cells in a representative patient before and at day 5 of treatment with G-CSF.

View larger version (25K): [in this window] [in a new window] [Download PPT slide]   Figure 3 Change of global ejection fraction assessed by magnetic resonance imaging from baseline (1 week after percutaneous coronary intervention) to 3 months of follow-up. G-CSF = granulocyte colony-stimulating factor; PCI = percutaneous coronary intervention. Bold squares = mean ± SD.