HOME SUBSCRIPTIONS CURRENT ISSUE PAST ISSUES CARDIOSOURCE SEARCH HELP FEEDBACK		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Abstract Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (2) Citing Articles via Google Scholar Google Scholar Articles by Abe, N. Articles by Okumura, K. Search for Related Content PubMed PubMed Citation Articles by Abe, N. Articles by Okumura, K.

Increased Level of Pericardial Insulin-Like Growth Factor-1 in Patients With Left Ventricular Dysfunction and Advanced Heart Failure

Naoki Abe, MD^_*, Toshiro Matsunaga, MD^_*, Kunihiko Kameda, MD^_*, Hirofumi Tomita, MD^_*, Takayuki Fujiwara, MD^_*, Hiroshi Ishizaka, MD^_*, Hiroyuki Hanada, MD^_*, Kozo Fukui, MD, Ikuo Fukuda, MD, Tomohiro Osanai, MD^_* and Ken Okumura, MD^_*,_*

^_* Second Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki, Japan
First Department of Surgery, Hirosaki University School of Medicine, Hirosaki, Japan.

View larger version (29K): [in this window] [in a new window] [Download PPT slide]   Figure 1 (A) Relationship between age and the plasma total insulin-like growth factor-1 (IGF-1) level. (B) Relationship between age and the pericardial total IGF-1 level. (C) Relationship between the plasma and pericardial brain natriuretic peptide (BNP) levels. (D) Relationship between the plasma and pericardial total IGF-1 levels.

View larger version (13K): [in this window] [in a new window] [Download PPT slide]   Figure 2 Pericardial total insulin-like growth factor-1 (IGF-1) levels (A), pericardial free IGF-1 levels (B), plasma total IGF-1 levels (C), and plasma brain natriuretic peptide (BNP) levels (D) in patient groups with left ventricular ejection fraction (LVEF) values of >50%, 30% to 50%, and <30%. *p < 0.01 compared with the LVEF >50% group.

View larger version (14K): [in this window] [in a new window] [Download PPT slide]   Figure 3 Pericardial total insulin-like growth factor-1 (IGF-1) levels (A), pericardial free IGF-1 levels (B), plasma total IGF-1 levels (C), and plasma brain natriuretic peptide (BNP) levels (D) in patient groups with New York Heart Association (NYHA) functional classes I, II, and III. *p < 0.05 compared with class I. **p < 0.001 compared with classes I and II.

View larger version (13K): [in this window] [in a new window] [Download PPT slide]   Figure 4 (A) Relationship between the plasma brain natriuretic peptide (BNP) and pericardial total insulin-like growth factor-1 (IGF-1) levels. (B) Relationship between the plasma BNP and pericardial free IGF-1 levels. (C) Relationship between the plasma BNP and plasma total IGF-1 levels.

View larger version (85K): [in this window] [in a new window] [Download PPT slide]   Figure 5 Different degrees of immunostaining for insulin-like growth factor-1 (IGF-1) and IGF-1 receptor proteins in endomyocardial biopsy samples obtained from 3 patients. 3+ = markedly enhanced staining; 2+ = moderate staining; 1+ = weak staining. See text for discussion.