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Benefit of a 600-mg Loading Dose of Clopidogrel on Platelet Reactivity and Clinical Outcomes in Patients With Non–ST-Segment Elevation Acute Coronary Syndrome Undergoing Coronary Stenting

Thomas Cuisset, MD^_*, Corinne Frere, MD, Jacques Quilici, MD^_*, Pierre-Emmanuel Morange, MD, PhD, Lyassine Nait-Saidi, MD^_*, Joseph Carvajal, MD, Agnès Lehmann, Marc Lambert, MD^_*, Jean-Louis Bonnet, MD^_* and Marie-Christine Alessi, MD, PhD^,_*

^_* Department of Cardiology, CHU Timone, Marseille, France
INSERM, Faculté de Médecine CHU Timone, Marseille, France

View larger version (16K): [in this window] [in a new window] [Download PPT slide]   Figure 1 Maximal intensity of adenosine diphosphate (ADP)-induced platelet aggregation in the 300-mg and 600-mg groups.

View larger version (14K): [in this window] [in a new window] [Download PPT slide]   Figure 2 Mean fluorescence intensity of P-selectin expression in the 300-mg and 600-mg groups. AU = arbitrary units.

View larger version (8K): [in this window] [in a new window] [Download PPT slide]   Figure 3 Clinical outcomes according to loading dose of clopidogrel. ACS = acute coronary syndrome; CV death = cardiovascular death; CVE = cardiovascular events; ST = stent thrombosis.

View larger version (7K): [in this window] [in a new window] [Download PPT slide]   Figure 4 Kaplan-Meier analysis for 30-day cardiovascular (CV) events according to loading dose of clopidogrel. Log-rank = 9.24, p < 0.0024.