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J Am Coll Cardiol, 2006; 48:1339-1345, doi:10.1016/j.jacc.2006.06.049 (Published online 11 September 2006).
© 2006 by the American College of Cardiology Foundation
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Benefit of a 600-mg Loading Dose of Clopidogrel on Platelet Reactivity and Clinical Outcomes in Patients With Non–ST-Segment Elevation Acute Coronary Syndrome Undergoing Coronary Stenting

Thomas Cuisset, MD*, Corinne Frere, MD{dagger}, Jacques Quilici, MD*, Pierre-Emmanuel Morange, MD, PhD{dagger}, Lyassine Nait-Saidi, MD*, Joseph Carvajal, MD{dagger}, Agnès Lehmann{dagger}, Marc Lambert, MD*, Jean-Louis Bonnet, MD* and Marie-Christine Alessi, MD, PhD{dagger},*

* Department of Cardiology, CHU Timone, Marseille, France
{dagger} INSERM, Faculté de Médecine CHU Timone, Marseille, France


Figure 1
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  		Figure 1 Maximal intensity of adenosine diphosphate (ADP)-induced platelet aggregation in the 300-mg and 600-mg groups.

 

Figure 2
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  		Figure 2 Mean fluorescence intensity of P-selectin expression in the 300-mg and 600-mg groups. AU = arbitrary units.

 

Figure 3
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  		Figure 3 Clinical outcomes according to loading dose of clopidogrel. ACS = acute coronary syndrome; CV death = cardiovascular death; CVE = cardiovascular events; ST = stent thrombosis.

 

Figure 4
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  		Figure 4 Kaplan-Meier analysis for 30-day cardiovascular (CV) events according to loading dose of clopidogrel. Log-rank = 9.24, p < 0.0024.

 




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Copyright © 2006 by the American College of Cardiology Foundation.