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A Randomized Clinical Trial of Trimetazidine, a Partial Free Fatty Acid Oxidation Inhibitor, in Patients With Heart Failure

Gabriele Fragasso, MD^_*,1,_*, Altin Palloshi, MD^_*, Patrizia Puccetti, MD^_*, Carmen Silipigni, MD^_*, Alessandra Rossodivita, MD, Mariagrazia Pala, MD, Giliola Calori, MDPhD^_*, Ottavio Alfieri, MD^_* and Alberto Margonato, MD, FESC^_*

^_* Clinical Cardiology-Heart Failure Unit, Istituto Scientifico-Universita Vita/Salute San Raffaele, Milan, Italy.
Cardiac Surgery, Istituto Scientifico-Universita Vita/Salute San Raffaele, Milan, Italy.

View larger version (12K): [in a new window]   Figure 1 Effect of trimetazidine and conventional therapy alone on quality of life (0% to 100%), at baseline (solid bars) and at follow-up (open bars). Compared with patients treated with conventional therapy alone, in whom a clear trend toward deterioration was observed, those treated with trimetazidine showed a significant improvement of quality of life.

View larger version (19K): [in a new window]   Figure 2 Individual effects of trimetazidine (A) and conventional therapy alone (B) on left ventricular ejection fraction (LVEF), at baseline, and at follow-up. Trimetazidine significantly improved LVEF, whereas a trend toward a decline in left ventricular function was observed in patients treated with conventional therapy alone.