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J Am Coll Cardiol, 2006; 48:931-938, doi:10.1016/j.jacc.2006.04.090 (Published online 15 August 2006).
© 2006 by the American College of Cardiology Foundation
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A Randomized Comparison of High Clopidogrel Loading Doses in Patients With Non–ST-Segment Elevation Acute Coronary Syndromes

The ALBION (Assessment of the Best Loading Dose of Clopidogrel to Blunt Platelet Activation, Inflammation and Ongoing Necrosis) Trial

Gilles Montalescot, MD, PhD*,1,*, Georges Sideris, MD{dagger}, Catherine Meuleman, MD{ddagger}, Claire Bal-dit-Sollier, MB§,1, Nicolas Lellouche, MD||, Ph. Gabriel Steg, MD,1, Michel Slama, MD#, Olivier Milleron, MD**, Jean-Philippe Collet, MD, PhD*, Patrick Henry, MD{dagger}, Farzin Beygui, MD, PhD*, Ludovic Drouet, MD, PhD§,1 for the ALBION Trial Investigators

* Institut de Cardiologie–Pitié-Salpêtriére University Hospital, Assistence Publique Hôpiteux de Paris (APHP), Paris, France.
{dagger} Service de Cardiologie–Lariboisiére University Hospital, APHP, Paris, France.
{ddagger} Service de Cardiologie–Saint-Antoine University Hospital, APHP, Paris, France.
§ Laboratoire d’Hémostase–Lariboisière University Hospital, APHP, Paris, France.
|| Service de Cardiologie–Henri-Mondor University Hospital, APHP, Paris, France.
Service de Cardiologie–Hôpital Bichat-Claude Bernard, APHP, Paris, France.
# Service de Cardiologie–Antoine Béclère University Hospital, APHP, Paris, France.
** Service de Cardiologie–Ambroise Paré University Hospital, APHP, Paris, France.


Figure 1
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  		Figure 1 (A) Percentage inhibition of platelet aggregation after stimulation with 5 µmol/l adenosine diphosphate (ADP). (B) Percentage inhibition of platelet aggregation after stimulation with 20 µmol/l ADP.

 

Figure 2
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  		Figure 2 Areas under the curves for inhibition of adenosine diphosphate (ADP)-induced platelet aggregation between 0 and 24 h. Error bars indicate standard deviations of the mean. AUC = area under the IPA curve.

 

Figure 3
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  		Figure 3 (Left) Mean fluorescence intensity (MFI) after the coadministration of PGE1 and adenosine diphosphate (ADP) at 6 h after dosing. (Right) Vasodilator-stimulated phosphoprotein (VASP) index at 6 h after dosing. Error bars indicate standard deviations of the mean.

 

Figure 4
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  		Figure 4 Proportion of patients with increased troponin over the course of 24 h.

 




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Copyright © 2006 by the American College of Cardiology Foundation.