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Renal Toxicity Evaluation and Comparison Between Visipaque (Iodixanol) and Hexabrix (Ioxaglate) in Patients With Renal Insufficiency Undergoing Coronary Angiography

The RECOVER Study: A Randomized Controlled Trial

Sang-Ho Jo, MD^_*,1, Tae-Jin Youn, MD^_*,1, Bon-Kwon Koo, MD^_*,_*, Jin-Shik Park, MD^_*, Hyun-Jae Kang, MD^_*, Young-Seok Cho, MD^_*, Woo-Young Chung, MD^_*, Gwon-Wook Joo, MD, In-Ho Chae, MD^_*, Dong-Ju Choi, MD^_*, Byung-Hee Oh, MD^_*, Myoung-Mook Lee, MD, Young-Bae Park, MD^_* and Hyo-Soo Kim, MD^_*,_*

^_* Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine/Cardiovascular Center, Seoul National University Hospital, Seoul, Korea
Division of Nephrology, Department of Internal Medicine, Seoul National University College of Medicine/Cardiovascular Center, Seoul National University Hospital, Seoul, Korea
Cardiovascular Center, Dongguk University International Hospital, Goyang-si, Gyeonggi-do, Korea.

View larger version (12K): [in a new window]   Figure 1 Flow of patients through the study.

View larger version (28K): [in a new window]   Figure 2 Incidence of contrast-induced nephropathy according to 3 definitions for patients receiving iodixanol and ioxaglate as contrast media for coronary angiography. SCr = serum creatinine.

View larger version (20K): [in a new window]   Figure 3 Changes in SCr concentration (baseline to peak) after contrast administration for coronary angiography. Baseline and peak SCr concentrations within 48 h after contrast administration are shown for each patient in the iodixanol (n = 140) and ioxaglate (n = 135) study arms. The vertical lines and symbols illustrate the mean (± SD) baseline and peak SCr values for the 2 groups as described in the text; p values refer to the difference between baseline and peak SCr for iodixanol and ioxaglate, respectively. See text for additional details. To convert values for creatinine to micromoles per liter, multiply by 88.4. mOsm/kg = milliosmoles per 1,000 grams; mPa·s = millipascal seconds; SCr = serum creatinine; SD = standard deviation.