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Coronary Artery Calcification and Myocardial Perfusion in Asymptomatic Adults

The MESA (Multi-Ethnic Study of Atherosclerosis)

Lu Wang, PhD^_*,, Michael Jerosch-Herold, PhD^,,_*, David R. Jacobs, Jr, PhD^_*,||, Eyal Shahar, MD^_*, Robert Detrano, MD^¶, Aaron R. Folsom, MD^_* for the MESA Study Investigators

^_* Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minnesota
Division of Preventive Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts
Department of Radiology, School of Medicine, University of Minnesota, Minneapolis, Minnesota
Advanced Imaging Research Center, Oregon Health and Science University, Portland, Oregon
^|| Department of Nutrition, University of Oslo, Oslo, Norway
^¶ Division of Cardiology, Harbor-UCLA Research and Education Institute, Torrance, California.

View larger version (60K): [in a new window]   Figure 1 (a) The first pass of an intravenous contrast agent bolus of gadolinium complex of diethylenetriamine pentaacetic acid (Gd-DTPA) through the right ventricle (RV) and left ventricle (LV) is shown in a short-axis view on 3 frames, out of a total of 50 for each slice, acquired by T1-weighted fast magnetic resonance imaging with a temporal resolution of 1 frame per heartbeat at each of 3 slice levels. (b) The myocardial signal enhancement in 1 of 8 myocardial sectors, located in the inferior wall, for baseline and hyperemia is analyzed by model-independent deconvolution with the respective arterial inputs, shown in c. The solid line in b represents the myocardial response calculated from the estimated tissue impulse response by convolution with the measured arterial input. SI = signal intensity.

View larger version (19K): [in a new window]   Figure 2 Prevalence of reduced perfusion reserve (<2.5) across levels of coronary artery calcification in subjects with no clinical coronary heart disease, stratified by age group. Numbers in bars are the number of subjects with reduced perfusion reserve/total n of subjects in the respective coronary artery calcium score category. Error bars show the standard error for prevalence obtained by a bootstrap estimate.