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J Am Coll Cardiol, 2006; 48:721-730, doi:10.1016/j.jacc.2006.03.051 (Published online 24 July 2006).
© 2006 by the American College of Cardiology Foundation
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Quality of Life and Exercise Performance in Patients in Sinus Rhythm Versus Persistent Atrial Fibrillation

A Veterans Affairs Cooperative Studies Program Substudy

Steven N. Singh, MD*,*, X. Charlene Tang, PhD, MD{dagger}, Bramah N. Singh, MD, DSc{ddagger}, Paul Dorian, MD**, Domenic J. Reda, PhD{dagger}, Crystal L. Harris, PharmD§, Ross D. Fletcher, MD*, Satish C. Sharma, MD||, J. Edwin Atwood, MD{dagger}{dagger}, Alan K. Jacobson, MD, H. Daniel Lewis, Jr, MD#, Becky Lopez, RN{ddagger}, Dennis W. Raisch, PhD§, Michael D. Ezekowitz, MD, PhD{ddagger}{ddagger} for the SAFE-T Investigators

* Department of Veterans Affairs Medical Center, Washington, DC
{dagger} Department of Veterans Affairs Medical Center, Hines, Illinois
{ddagger} Department of Veterans Affairs Medical Center, West Los Angeles, California
§ Department of Veterans Affairs Medical Center, Albuquerque, New Mexico
|| Department of Veterans Affairs Medical Center, Providence, Rhode Island
Department of Veterans Affairs Medical Center, Loma Linda, California
# Department of Veterans Affairs Medical Center, Kansas City, Missouri
** Department of Veterans Affairs Medical Center, University of Toronto, Toronto, Canada
{dagger}{dagger} Department of Veterans Affairs Medical Center, Walter Reed Army Medical Center, Washington, DC
{ddagger}{ddagger} Department of Veterans Affairs Medical Center, Lankenau Institute for Medical Research, Philadelphia, Pennsylvania


Figure 1
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  		Figure 1 Sinus rhythm (SR) versus atrial fibrillation (AF) comparisons on mean changes in quality-of-life scores from baseline to 8 weeks by presence of AF symptoms. *p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001. (A) Symptomatic patients (SR group: n = 167; AF group: n = 179). (B) Asymptomatic patients (SR group: n = 116; AF group: n = 92). SCL = symptom checklist; SF-36 = Short Form-36.

 

Figure 2
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  		Figure 2 Sinus rhythm (SR) versus atrial fibrillation (AF) comparisons on comparison of mean changes in quality-of-life scores from baseline to 1 year by presence of AF symptoms. *p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001. (A) Symptomatic patients (SR group: n = 202; AF group: n = 111). (B) Asymptomatic patients (SR group: n = 118; AF group: n = 65). SCL = symptom checklist; SF-36 = Short Form-36.

 

Figure 3
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  		Figure 3 Sinus rhythm (SR) versus atrial fibrillation (AF) comparisons on mean increase in maximal exercise duration from baseline to 8 weeks and from baseline to 1 year. {dagger}SR group: n = 213; AF group: n = 145. {ddagger}SR group: n = 219; AF group: n = 113.

 




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