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J Am Coll Cardiol, 2006; 48:715-720, doi:10.1016/j.jacc.2006.04.080 (Published online 21 July 2006).
© 2006 by the American College of Cardiology Foundation
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Consumption of Saturated Fat Impairs the Anti-Inflammatory Properties of High-Density Lipoproteins and Endothelial Function

Stephen J. Nicholls, MBBS, PhD, FRACP, FACC*,{dagger}, Pia Lundman, MD, PhD, FESC*,{ddagger},§, Jason A. Harmer, BSc (Hons){ddagger}, Belinda Cutri, BMedSc (Hons)*, Kaye A. Griffiths, DMU{ddagger}, Kerry-Anne Rye, PhD*, Philip J. Barter, MBBS, PhD, FRACP*,|| and David S. Celermajer, MBBS, PhD, FRACP*,{ddagger},||,*

* The Heart Research Institute, Sydney, Australia
{dagger} Department of Medicine, University of Adelaide, Adelaide, Australia
{ddagger} Department of Cardiology, Royal Prince Alfred Hospital, Sydney, Australia
§ Division of Medicine, Karolinska Institutet, Danderyd University Hospital, Stockholm, Sweden
|| Department of Medicine, University of Sydney, Sydney, Australia.


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  		Figure 1 Expression of intercellular adhesion molecule-1 (ICAM-1) (A) and vascular cell adhesion molecule-1 (VCAM-1) (B) by activated human umbilical vein endothelial cells after incubation with high-density lipoprotein (HDL) isolated after a meal enriched with a polyunsaturated (open bars) or saturated (gray bars) fat. Cells were incubated with HDL at an apolipoprotein A-I concentration of 8 µmol/l. Results are expressed as percentage of expression in the presence of HDL isolated from fasting blood (solid bars) (mean ± SEM). For difference between the meals: *p = 0.007; **p = 0.005. A significant meal-time period interaction was found for both ICAM-1 (p = 0.01) and VCAM-1 (p = 0.04).

 




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Copyright © 2006 by the American College of Cardiology Foundation.