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The Effects of Diet on Inflammation

Emphasis on the Metabolic Syndrome

Dario Giugliano, MD, PhD^_*,_*, Antonio Ceriello, MD and Katherine Esposito, MD, PhD^_*

^_* Division of Metabolic Diseases, Center of Excellence for Cardiovascular Diseases, University of Naples SUN, Italy
Warwick Medical School, Coventry, United Kingdom

View larger version (18K): [in a new window]   Figure 1 Some mechanisms through which unhealthy dietary patterns may lead to coronary heart disease (CHD). LDL = low-density lipoprotein.

View larger version (20K): [in a new window]   Figure 2 Mechanisms through which hyperglycemia may generate inflammatory responses. NF-kB = nuclear factor kappa B; PKC = protein kinase C.

View larger version (29K): [in a new window]   Figure 3 Effects of a 2-year dietetic approach with a Mediterranean-style diet in patients with the metabolic syndrome. The number of components of the syndrome was reduced approximately by one-half in the intervention group (100).

View larger version (24K): [in a new window]   Figure 4 Healthy dietary patterns contribute to a lower generation of a proinflammatory milieu, which in turn may decrease the incidence of metabolic syndrome, type 2 diabetes, and coronary heart disease (CHD). CRP = C-reactive protein; IL = interleukin; TNF = tumor necrosis factor.