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J Am Coll Cardiol, 2006; 48:508-515, doi:10.1016/j.jacc.2006.04.074 (Published online 11 July 2006).
© 2006 by the American College of Cardiology Foundation
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Identification of a Cytochrome P450 2C9-Derived Endothelium-Derived Hyperpolarizing Factor in Essential Hypertensive Patients

Stefano Taddei, MD*, Daniele Versari, MD, Alessandro Cipriano, MD, Lorenzo Ghiadoni, MD, PhD, Fabio Galetta, MD, Ferdinando Franzoni, MD, Armando Magagna, MD, Agostino Virdis, MD and Antonio Salvetti, MD

Department of Internal Medicine, University of Pisa, Pisa, Italy.


Figure 1
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  		Figure 1 Forearm blood flow (FBF) percent increase above basal induced by acetylcholine and bradykinin during saline, NG-monomethyl-L-arginine (L-NMMA), or sulfaphenazole in normotensive subjects (n = 12) and essential hypertensive patients (n = 12). The lower panels show FBF percent increase above basal induced by sodium nitroprusside (SNP) with or without sulfaphenazole. Data shown as mean ± SEM. *p < 0.001; {dagger}p < 0.05; {ddagger}p < 0.01 (by analysis of variance for repeated measures and Scheffé’s test).

 

Figure 2
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  		Figure 2 Percent inhibition by sulfaphenazole on maximal response to acetylcholine (Ach) or bradykinin (Bdk) in normotensive subjects and essential hypertensive patients in control condition (saline) and under vitamin C. Data shown as mean ± SEM. *p < 0.001 versus other groups; {dagger}p < 0.05 versus Ach under saline in hypertensive patients (by analysis of variance and Scheffs test).

 

Figure 3
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  		Figure 3 Forearm blood flow (FBF) percent increase above basal induced by acetylcholine (n = 8) and bradykinin (n = 8) during saline, NG-monomethyl-L-arginine (L-NMMA), sulfaphenazole, and L-NMMA plus sulfaphenazole, in normotensive subjects. Data shown as mean ± SEM. *p < 0.001; {dagger}p < 0.01 (by analysis of variance for repeated measures and Scheffé’s test).

 

Figure 4
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  		Figure 4 Forearm blood flow (FBF) percent increase above basal induced by acetylcholine (upper panels) and bradykinin (lower panels) during saline or sulfaphenazole, at baseline (control) and under vitamin C in essential hypertensive patients. Data shown as mean ± SEM. *p < 0.05; {dagger}p < 0.01 (by analysis of variance for repeated measures and Scheffé’s test).

 




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