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Insulin Therapy Is Associated With Platelet Dysfunction in Patients With Type 2 Diabetes Mellitus on Dual Oral Antiplatelet Treatment

Dominick J. Angiolillo, MD, PhD, FACC^_*,1,_*, Esther Bernardo, BSc, Celia Ramírez, BSc, Marco A. Costa, MD, PhD, FACC^_*, Manel Sabaté, MD, PhD, Pilar Jimenez-Quevedo, MD, Rosana Hernández, MD, PhD, Raul Moreno, MD, Javier Escaned, MD, PhD, Fernando Alfonso, MD, PhD, Camino Bañuelos, MD, Theodore A. Bass, MD, FACC^_*, Carlos Macaya, MD, PhD and Antonio Fernandez-Ortiz, MD, PhD

^_* Division of Cardiology, University of Florida, Shands Jacksonville, Jacksonville, Florida
Cardiovascular Institute, San Carlos University Hospital, Madrid, Spain.

View larger version (15K): [in a new window]   Figure 1 Platelet aggregation after 6 and 20 µM adenosine diphosphate (ADP) stimuli in noninsulin-treated diabetes mellitus (NITDM; open bars) and insulin-treated diabetes mellitus (ITDM; solid bars).

View larger version (26K): [in a new window]   Figure 2 Platelet aggregation after 6 (left) and 20 (right) µM adenosine diphosphate (ADP) stimuli in nondiabetic patients (NDM; dotted bars), noninsulin-treated diabetes mellitus (NITDM; open bars) and insulin-treated diabetes mellitus (ITDM; solid bars).