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Insulin Resistance as a Determinant of Platelet Activation in Obese Women

Stefania Basili, MD, Giovanni Pacini, DSC, Maria Teresa Guagnano, MD^_*, Maria Rosaria Manigrasso, MD^_*, Francesca Santilli, MD^_*, Caterina Pettinella, BS^_*, Giovanni Ciabattoni, MD^_*, Carlo Patrono, MD and Giovanni Davì, MD^_*,_*

^_* Center of Excellence on Aging and Departments of Medicine and Drug Sciences, University of Chieti "G. D’Annunzio" Schools of Medicine and Pharmacy, Chieti, Italy
Metabolic Unit, Institute of Biomedical Engineering, National Research Council, Padova, Italy
Department of Medical Therapy, University of Rome "La Sapienza," Rome, Italy
Department of Pharmacology, University of Rome "La Sapienza," Rome, Italy

View larger version (32K): [in this window] [in a new window] [Download PPT slide]   Figure 1 Urinary 11-dehydro-thromboxane B2 (11-dehydro-TXB2) excretion in obese women. Urinary 11-dehydro-TXB2 excretion in android obesity (waist-to-hip ratio 0.86, n = 25) and in gynoid obesity (waist-to-hip ratio <0.86, n = 15) according to normal or impaired insulin sensitivity (insulin sensitivity index [SI] above or below the median value of 2.5 104 min–1/[µU/ml]).

View larger version (28K): [in this window] [in a new window] [Download PPT slide]   Figure 2 Effects of weight loss or pioglitazone on urinary 11-dehydro-thromboxane B2 (11-dehydro-TXB2). Effects of weight loss or pioglitazone treatment on urinary 11-dehydro-TXB2 excretion in android obese women with impaired insulin sensitivity. Mean ± SD percentage of baseline metabolite excretion rates are represented for 15 women participating in the 2 studies. The p values were assessed by Wilcoxon signed rank test.