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The Relative Strength of C-Reactive Protein and Lipid Levels as Determinants of Ischemic Stroke Compared With Coronary Heart Disease in Women

Brendan M. Everett, MD^_*,,,,_*, Tobias Kurth, MD, ScD^_*,||,¶, Julie E. Buring, ScD^_*,,,|| and Paul M. Ridker, MD, MPH, FACC^_*,,,||

^_* Division of Preventive Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts
Center for Cardiovascular Disease Prevention, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts
Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
Donald W. Reynolds Cardiovascular Clinical Research Center on Atherosclerosis at Brigham and Women’s Hospital and the Harvard Medical School, Boston, Massachusetts
^|| Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts
^¶ Division of Aging, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts

View larger version (16K): [in this window] [in a new window] [Download PPT slide]   Figure 1 Adjusted hazard ratios (HR) and 95% confidence intervals (CI) for future ischemic stroke (open circles) and coronary heart disease (closed circles) among those in extreme tertiles of each lipid variable and high-sensitivity C-reactive protein (Hs-CRP). Hazard ratios are adjusted for age (years), blood pressure (Framingham categories), diabetes, current smoking status, body mass index, and randomized treatment assignment. For ease of comparison, we have used the highest tertile as the referent for high-density lipoprotein cholesterol (HDL-C) and apolipoprotein (Apo) A-I. Apo B100 = apolipoprotein B100; LDL-C = low-density lipoprotein-cholesterol; Tot Chol = total cholesterol.

View larger version (20K): [in this window] [in a new window] [Download PPT slide]   Figure 2 Adjusted hazard ratios and 95% confidence intervals for future ischemic stroke (open circles) and coronary heart disease (closed circles) among those in extreme tertiles of each lipid ratio. Hazard ratios are adjusted for age (years), blood pressure (Framingham categories), diabetes, current smoking status, body mass index, and randomized treatment assignment. Abbreviations as in Figure 1.