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The Role of Clopidogrel in Early and Sustained Arterial Patency After Fibrinolysis for ST-Segment Elevation Myocardial Infarction

The ECG CLARITY–TIMI 28 Study

Benjamin M. Scirica, MD, MPH^_*,,_*, Marc S. Sabatine, MD, MPH^_*,, David A. Morrow, MD, MPH, FACC^_*,, C. Michael Gibson, MD, MSc, FACC^,, Sabina A. Murphy, MPH^_*,, Stephen D. Wiviott, MD^_*,, Robert P. Giugliano, MD, SM, FACC^_*,, Carolyn H. McCabe, BS^_*,, Christopher P. Cannon, MD, FACC^_*, and Eugene Braunwald, MD, MACC^_*,

^_* TIMI Study Group, Cardiovascular Division, Brigham and Women’s Hospital, Boston, Massachusetts
TIMI Study Group, Cardiovascular Division, Beth Israel Deaconess Medical Center, Boston, Massachusetts
Department of Medicine, Harvard Medical School, Boston, Massachusetts.

View larger version (20K): [in a new window]   Figure 1 Schema of the CLARITY–TIMI 28 trial. Determination of early reperfusion was assessed by analyzing ST-segment resolution and late patency by angiography (median 3.5 days after randomization). ECG = electrocardiogram.

View larger version (25K): [in a new window]   Figure 2 Rates of Thrombolysis In Myocardial Infarction (TIMI) flow grade according to both ST-segment resolution (STRes) and treatment strategy. p = 0.003 for interaction between STRes category and treatment. CI = confidence interval; OR = odds ratio.

View larger version (24K): [in a new window]   Figure 3 The rates of in-hospital cardiovascular death or myocardial infarction (MI) according to both ST-segment resolution (STRes) at 90 min and treatment strategy. p = 0.027 for interaction between STRes category and treatment. CI = confidence interval; OR = odds ratio.

View larger version (28K): [in a new window]   Figure 4 The rates of cardiovascular death or myocardial infarction (MI) (A) and cardiovascular death alone (B) at 30 days according to both ST-segment resolution (STRes) and treatment strategy. p = 0.026 for interaction between STRes category and treatment for death or MI and 0.179 for death alone. CI = confidence interval; OR = odds ratio.