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Post-Reperfusion Myocardial Infarction

Long-Term Survival Improvement Using Adenosine Regulation With Acadesine

Ischemia Research and Education Foundation (IREF), San Bruno, California

View larger version (32K): [in a new window]   Figure 1 Consort diagram for the study patients. *Myocardial infarction (MI) indicates large, acute ST-segment elevation MI requiring either: 1) the presence of a new Q-wave on electrocardiogram and new post-reperfusion elevation of the MB isoform of creatine kinase (100 ng/ml anytime after removal of cross clamp, with a bordering value of 50% or more; or 70% ng/ml anytime after 12 h after removal of cross clamp with a bordering value of 50% or more; or 70 ng/ml anytime after 36 h after removal of cross clamp); or 2) the presence of autopsy evidence of infarction. CABG = coronary artery bypass graft; CPB = cardiopulmonary bypass.

View larger version (15K): [in a new window]   Figure 2 Kaplan-Meier analysis of 2-year survival according to with or without postoperative myocardial infarction (MI) among the 2,698 study patients.

View larger version (35K): [in a new window]   Figure 3 (A) Kaplan-Meier analysis of 2-year survival according to the use or non-use of acadesine among the 100 study patients who sustained post-reperfusion myocardial infarction (MI). (B) Two-year mortality by-MI and by-treatment.

View larger version (23K): [in a new window]   Figure 4 Two-year mortality: acadesine versus placebo by patient characteristic. ASA = acetylsalicylic acid; BB = beta-blocker; CABG = coronary artery bypass graft; CCB = calcium channel blocker; CHF = congestive heart failure; DYS = dysrhythmia; HX = history of; LLA = lipid-lowering agents; MI = myocardial infarction; PTCA = percutaneous transluminal coronary angioplasty; UA = unstable angina.