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J Am Coll Cardiol, 2006; 47:1850-1857, doi:10.1016/j.jacc.2005.12.054 (Published online 17 April 2006).
© 2006 by the American College of Cardiology Foundation
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The Relationship Between Plasma Osteoprotegerin Levels and Coronary Artery Calcification in Uncomplicated Type 2 Diabetic Subjects

Dhakshinamurthy Vijay Anand, MBBS, MRCP*,{dagger},{ddagger},*, Avijit Lahiri, MBBS, MSc, MRCP, FACC, FESC*, Eric Lim, MBChB, MA, MRCP*, David Hopkins, BSc, MBChB, FRCP§ and Roger Corder, PhD, MRPharmS{dagger}

* Cardiac Imaging and Research Centre, Wellington Hospital, London, United Kingdom
{dagger} William Harvey Research Institute, Barts and The London, Queen Mary’s School of Medicine and Dentistry, London, United Kingdom
{ddagger} Department of Cardiology, Royal Free Hospital, London, United Kingdom
§ Department of Endocrinology, Kings College Hospital, London, United Kingdom.


Figure 1
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  		Figure 1 Box and whisker plots illustrate the median and interquartile ranges of osteoprotegerin (OPG) in patients with minimal, mild, moderate, severe, and extensive coronary calcification respectively. Open circles show outliers (values between 1.5 and 3 box lengths from the upper edge of the box) and asterisks show extreme outliers (values >3 box lengths from the upper edge of the box).

 

Figure 2
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  		Figure 2 The correlation between markers of inflammation (high-sensitivity C-reactive protein [hs-CRP, in mg/l], interleukin [IL]-6 [in pg/ml]) and the coronary calcium (CAC) score. Log transformation was applied to normalize the distribution of hs-CRP and IL-6 and to reduce the skew of CAC scores.

 

Figure 3
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  		Figure 3 Event-free survival at 18 ± 5 months by the Cox proportional hazards model according to the extent of coronary calcification level (A) and plasma osteoprotegerin (OPG) level (B), respectively. RR = relative risk ratio.

 

Figure 4
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  		Figure 4 Receiver-operating characteristic curve analysis showing the prognostic value of coronary calcium (CAC) scores, osteoprotegerin (OPG) levels, and United Kingdom Prospective Diabetes Study (UKPDS) and Framingham risk scores in predicting cardiovascular events. The 95% confidence intervals are provided. AUC = area under the curve.

 




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Copyright © 2006 by the American College of Cardiology Foundation.