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J Am Coll Cardiol, 2006; 47:1803-1810, doi:10.1016/j.jacc.2005.12.047 (Published online 11 April 2006).
© 2006 by the American College of Cardiology Foundation
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Oxidized Low-Density Lipoprotein in Children With Familial Hypercholesterolemia and Unaffected Siblings

Effect of Pravastatin

Jessica Rodenburg, MD*, Maud N. Vissers, PhD*, Albert Wiegman, MD, PhD{dagger}, Elizabeth R. Miller, BS{ddagger}, Paul M. Ridker, PhD, MD, FACC§, Joseph L. Witztum, MD{ddagger}, John J.P. Kastelein, PhD, MD* and Sotirios Tsimikas, MD, FACC{ddagger},*

* Department of Vascular Medicine, University of Amsterdam, Amsterdam, the Netherlands
{dagger} Department of Paediatrics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
{ddagger} Department of Medicine, University of California, San Diego, California
§ Center for Cardiovascular Disease Prevention and Department of Medicine, Harvard Medical School, Boston, Massachusetts


Figure 1
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  		Figure 1 Relationship between oxidized phospholipid (OxPL)/apoprotein B-100 (apoB) and lipoprotein (a) [Lp(a)] in the entire cohort of children with familial hypercholesterolemia at baseline (top) and after two years of pravastatin therapy (bottom). RLU = relative light units.

 

Figure 2
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  		Figure 2 Mean percent change (with 95% confidence intervals [CIs]) in OxLDL markers from baseline to two years in the placebo and pravastatin groups. Abbreviations as in Table 1.

 




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