Fourth Annual American College of Cardiology International Lecture
A Journey in the Interventional Field
Patrick W. Serruys, MD, PhD, FESC, FACC*
Thoraxcenter, Erasmus Medical Center, Rotterdam, the Netherlands.
View larger version (21K):
[in a new window]
|
Figure 1 The rosy prophecy. ARTS = Arterial Revascularization Therapies Study; CABG = coronary artery bypass graft; CABRI = Coronary Angioplasty versus Bypass Revascularization Investigation; MI = myocardial infarction; PTCA = percutaneous transluminal coronary angioplasty.
|
|
View larger version (114K):
[in a new window]
|
Figure 2 Endothelial progenitor cell capture stent. (A) Bare stent; (B) coated stent.
|
|
View larger version (36K):
[in a new window]
|
Figure 3 (A) Normal mechanism of vessel stress; (B) effect of a device eluting nitric oxide. SMC = smooth muscle cell.
|
|
View larger version (39K):
[in a new window]
|
Figure 4 Where we have come from and where we are going: the next innovative steps in vascular intervention.
|
|
View larger version (43K):
[in a new window]
|
Figure 5 The "new diagnostic world" of the vulnerable plaque.
|
|
View larger version (97K):
[in a new window]
|
Figure 6 (A) Angiographic image of an intermediate lesion in the proximal right coronary artery; (B) corresponding multislice computed tomographic image of the lesion (vertical view); (C) corresponding multislice computed tomographic image of the lesion (horizontal view); (D) enlarged view of the clacified plaque in panel C; and (E) corresponding intravascular ultrasonic image of the calcified plaque. AV = atrioventricular.
|
|
View larger version (26K):
[in a new window]
|
Figure 7 Multislice computed tomography (MSCT) plaque burden: an ubiquitous phenomenon. Results: distribution of any plaque-% (large plaque-%). LCA = left coronary artery; RCA = right coronary artery.
|
|
View larger version (34K):
[in a new window]
|
Figure 8 Diagnostic value of palpography. CRP = C-reactive protein; ROC = receiver-operating characteristic.
|
|
View larger version (99K):
[in a new window]
|
Figure 9 Virtual histology or ... how to convert an ex vivo (pressurized) intravascular ultrasound image into a color-coded histological cross section. (A) Intravascular ultrasound cross section; (B) in vivo virtual histology color-coded of same cross section; (C) ex vivo histology of same cross section; (D) color pencil sketch of ex vivo histology cross section.
|
|
View larger version (74K):
[in a new window]
|
Figure 10 Optical coherence tomography showing detailed three layer resolution of a coronary vessel.
|
|
View larger version (130K):
[in a new window]
|
Figure 11 (A) Optical coherence tomography showing thin cap fibrous atheroma and (B and C) intramuscular capillary.
|
|
View larger version (22K):
[in a new window]
|
Figure 12 Vulnerable plaque triage. CRP = C-reactive protein; DES = drug-eluting stents; EEM = external elastic membrane.
|
|
View larger version (61K):
[in a new window]
|
Figure 13 Phantom made of cryogel mimicking a total occlusion of which the cross section is seen by a forward-looking (60°) optical coherence imaging wire (0.014 inch). OCT = optical coherence tomography.
|
|
View larger version (127K):
[in a new window]
|
Figure 14 Has the myocardium its own stem cells? Arrows = C-Kit+ cells. C-Kit is an antigen of staminality. Its expression is a proof of staminal potential of these cells. These cells are still uncommitted. Arrowheads = cells expressing MEF2C. MEF2C is a transcription factor expressed early in the myocyte lineage. These cells are committed early to myocyte lineage. *Alpha-sarcomeric actin. This cell is engaged in a more advanced stage of myocyte lineage. Reprinted, with permission, from Beltrami et al. (66).
|
|
|
