This Article Abstract Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (16) Citing Articles via Google Scholar Google Scholar Articles by Petrakopoulou, P. Articles by Weis, M. Search for Related Content PubMed PubMed Citation Articles by Petrakopoulou, P. Articles by Weis, M.

Coronary Endothelial Vasomotor Function and Vascular Remodeling in Heart Transplant Recipients Randomized for Tacrolimus or Cyclosporine Immunosuppression

Paraskevi Petrakopoulou, MD^_*, Lydia Anthopoulou, MD, Michael Muscholl, MD^_*, Volker Klauss, MD, Wolfgang von Scheidt, MD^¶, Peter Überfuhr, MD, Bruno M. Meiser, MD, Bruno Reichart, MD and Michael Weis, MD^_*,_*

^_* Medizinische Klinik und Poliklinik I, Ludwig-Maximilians University of Munich, Munich, Germany
Herzchirurgische Klinik, Klinikum Grosshadern, Ludwig-Maximilians University of Munich, Munich, Germany
Mathematisches Institut, Ludwig-Maximilians University of Munich, Munich, Germany
Medizinische Poliklinik des Klinikum Innenstadt, Ludwig-Maximilians University of Munich, Munich, Germany
^¶ Zentralklinikum Augsburg, Augsburg, Germany

View larger version (8K): [in a new window]   Figure 1 Mean intimal area (left anterior descending artery) detected by intravascular ultrasound. The mean intimal area significantly increased in the cyclosporin A (open bars) versus the tacrolimus (closed bars) group during follow-up (change from baseline to follow-up: p < 0.05). baseline to follow-up = absolute change from baseline to follow-up. *p < 0.05 versus cyclosporin A.

View larger version (8K): [in a new window]   Figure 2 Mean vessel area (left anterior descending [LAD]) detected by intravascular ultrasound. The mean vessel area significantly increased in the tacrolimus (closed bars) versus the cyclosporin A (open bars) group during follow-up (change from baseline to follow-up: p < 0.05). baseline to follow-up = absolute change from baseline to follow-up. *p < 0.05 versus cyclosporin A.

View larger version (8K): [in a new window]   Figure 3 Circulating plasma endothelin 1 (ET-1) concentrations (radioimmunoassay). The circulating ET-1 concentration in the tacrolimus (closed bars) (but not in the cyclosporin A [open bars]) group decreased during the first 12 postoperative months. The absolute change in ET-1 concentration during follow-up was significantly different between the groups (p 0.05). baseline to follow-up = absolute change from baseline to follow-up. *p < 0.05 versus cyclosporin A.