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J Am Coll Cardiol, 2006; 47:1379-1381, doi:10.1016/j.jacc.2006.01.034 (Published online 14 March 2006).
© 2006 by the American College of Cardiology Foundation
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C-Reactive Protein and the Vascular Endothelium

Implications for Plaque Instability*

Ishwarlal Jialal, MD, PhD*, Sridevi Devaraj, PhD and Uma Singh, PhD

Laboratory for Atherosclerosis and Metabolic Research, University of California at Davis Medical Center, Sacramento, California


Figure 1
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Figure 1 Effects of C-reactive protein (CRP) on the vascular endothelium. CAMS = cell adhesion molecules; eNOS = endothelial nitric oxide synthase; Fc{gamma} = fragment of antibody with the c-terminal of immunoglobulin chain; IL = interleukin; MAPK = mitogen-activated protein kinase; MCP 1 = monocyte chemotactic protein-1; MMP-1 = matrix metalloproteinase-1; NFKb = nuclear factor kb; PAI-1 = plasminogen activator inhibitor-1; TNF = tumor necrosis factor; tPA = tissue plasminogen activator.

 





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