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Two-Year Outcomes After Sirolimus-Eluting Stent Implantation

Results From the Sirolimus-Eluting Stent in de Novo Native Coronary Lesions (SIRIUS) Trial

Giora Weisz, MD^_*, Martin B. Leon, MD^_*,_*,1, David R. Holmes, Jr, MD, Dean J. Kereiakes, MD, Mel R. Clark, MD, Barry M. Cohen, MD^¶,2, Stephen G. Ellis, MD^||,3, Patrick Coleman, MD^#, Carolyn Hill^_**, Chunxue Shi, MS, Donald E. Cutlip, MD, Richard E. Kuntz, MD, MSc and Jeffrey W. Moses, MD^_*,4

^_* Cardiovascular Research Foundation and Columbia University Medical Center, New York, New York
Saint Mary’s Hospital, Rochester, Minnesota
Ohio Heart Health Center, Cincinnati, Ohio
Intergris Oklahoma Heart Center, Oklahoma City, Oklahoma
^¶ Morristown Memorial Hospital, Morristown, New Jersey
^|| Cleveland Clinic Foundation, Cleveland, Ohio
^# Northern California Research Association, Santa Rosa, California
^_** Cordis (Johnson & Johnson), Warren, New Jersey
Harvard Clinical Research Institute, Boston, Massachusetts
Beth Israel Deaconess Medical Center, Boston, Massachusetts
Brigham and Women’s Hospital, Boston, Massachusetts

View larger version (27K): [in a new window]   Figure 1 Kaplan-Meier event-free survival at two years for target lesion revascularization (TLR), major adverse coronary events (MACE), and target vessel failure (TVF). p < 0.001 for all comparisons of sirolimus-eluting stent (SES) vs. control bare-metal stent.

View larger version (24K): [in a new window]   Figure 2 Odds ratios for target lesion revascularization at 720 days for the overall population and by subgroup. Values represent event rates (%) in each arm by subgroup. Bars represent odds ratio point estimates and 95% confidence intervals (CI). LAD = treatment of lesions in the left anterior descending artery.