Relationship Between Increasing Body Weight, Insulin Resistance, Inflammation, Adipocytokine Leptin, and Coronary Circulatory Function
Thomas H. Schindler, MD*,
Jerson Cardenas, MD*,
John O. Prior, MD, PhD*,
Alvaro D. Facta, MD*,
Michael C. Kreissl, MD*,
Xiao-Li Zhang, MD, PhD*,
James Sayre, PhD*,
Magnus Dahlbom, PhD*,
Julio Licinio, MD and
Heinrich R. Schelbert, MD, PhD*,*
* Departments of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, California
Departments of Psychiatry and Biobehavioral Science and Medicine/Endocrinology, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, California
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Figure 1 Myocardial blood flow (MBF) at rest, during cold pressor testing (CPT), and during pharmacologic vasodilation with dipyridamole for the three study groups (significant difference by t test).
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Figure 2 Change of myocardial blood flow ( MBF) during cold pressor testing (CPT) for the three study groups (significant difference by t test).
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Figure 3 Correlation between leptin plasma levels and change of myocardial blood flow (MBF) during cold pressor testing (CPT) in the entire study group.
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Figure 4 Correlation between leptin plasma levels and change of myocardial blood flow (MBF) during cold pressor testing (CPT) in the overweight group.
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Figure 5 Correlation between leptin plasma levels and change of myocardial blood flow (MBF) during cold pressor testing (CPT) in the obese group.
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