Relationship Between Atheroma Regression and Change in Lumen Size After Infusion of Apolipoprotein A-I Milano
Stephen J. Nicholls, MBBS, PhD,
E. Murat Tuzcu, MD,
Ilke Sipahi, MD,
Paul Schoenhagen, MD,
Tim Crowe, BS,
Samir Kapadia, MD and
Steven E. Nissen, MD*
Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio
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Figure 1 Correlation between the change in plaque volume and the change in lumen volume (A) and external elastic membrane (EEM) volume (B) in the 10-mm segments harboring the greatest plaque burden at baseline after infusion of phospholipid:apolipoprotein A-I Milano complexes (ETC-216).
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Figure 2 Representative cross-sectional intravascular ultrasound images of matched arterial segments at baseline (left) and follow-up (right). At sites that underwent atheroma regression in response to infusions of reconstituted high-density lipoprotein cholesterol containing recombinant human apolipoprotein A-I Milano (top and middle panels), there was concomitant reduction in external elastic membrane (EEM) area with no change in the lumen size. At sites where there was no change in plaque area (bottom panels), there was no change in either the EEM or lumen.
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