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J Am Coll Cardiol, 2006; 47:981-986, doi:10.1016/j.jacc.2005.10.053 (Published online 8 February 2006).
© 2006 by the American College of Cardiology Foundation
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Intense Vasoconstriction in Response to Aspirate From Stented Saphenous Vein Aortocoronary Bypass Grafts

Kirsten Leineweber, PhD*, Dirk Böse, MD{dagger}, Magdalene Vogelsang, MSc*, Michael Haude, MD, FACC{dagger}, Raimund Erbel, MD, FACC{dagger} and Gerd Heusch, MD, FACC*,*

* Institute of Pathophysiology, University of Essen School of Medicine, Essen, Germany
{dagger} Department of Cardiology, University of Essen School of Medicine, Essen, Germany


Figure 1
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  		Figure 1 Vasoconstrictor action of venous blood (VB, open circles/closed circles) and aspirate plasma (AS, open squares/closed squares) on rat mesenteric arteries with intact (open symbols = +E) and denuded endothelium (filled symbols = –E). Values are mean ± SEM of 14 patients. *p < 0.05 vs. AS–E; #p < 0.05 vs. VB+E, p < 0.05 with Bonferroni correction for six comparisons.

 

Figure 2
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  		Figure 2 Vasoconstrictor action of arterial blood (AB, open triangles/closed triangles) taken distal to the lesion and aspirate plasma (AS, open squares/closed squares) on rat mesenteric arteries with intact (open symbols = +E) and denuded endothelium (filled symbols = –E). Values are mean ± SEM of five patients. *p < 0.05 vs. AS–E; #p < 0.05 vs. AS+E with Bonferroni correction for six comparisons.

 

Figure 3
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  		Figure 3 Vasoconstrictor action of aspirate plasma in the absence (open squares/closed squares AS+/–E) and in the presence of 1 µmol/l ketanserin (5-HT2A/2C-receptor blocker) and 0.1 µmol/l pindolol (ß-adrenoceptor and 5-HT1A/1B-receptor blocker) (open diamonds/closed diamonds AS+/–E with 5-HT-R blockade) or in the presence of 1 µmol/l ketanserin, 0.1 µmol/l pindolol, and 10 µmol/l ICI 185,282 (thromboxane A2 TP-receptor blocker) (open inverted triangles/closed inverted triangles AS+/–E with 5-HT and TP-R blockade) on rat mesenteric arteries with intact (open symbols = +E) and denuded endothelium (filled symbols = –E). Values are mean ± SEM of 14 patients. *p < 0.05 vs. AS–E; #p < 0.05 vs. AS+E with Bonferroni correction for 15 comparisons.

 




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