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J Am Coll Cardiol, 2006; 47:1005-1011, doi:10.1016/j.jacc.2005.09.063 (Published online 8 February 2006).
© 2006 by the American College of Cardiology Foundation
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The Relationship Between Plasma Levels of Oxidized and Reduced Thiols and Early Atherosclerosis in Healthy Adults

Salman Ashfaq, MD, FACC*, Jerome L. Abramson, PhD{dagger}, Dean P. Jones, PhD{ddagger}, Steven D. Rhodes, RN{dagger}, William S. Weintraub, MD, FACC{dagger}, W. Craig Hooper, PhD§, Viola Vaccarino, MD, PhD{dagger}, David G. Harrison, MD, FACC{dagger} and Arshed A. Quyyumi, MD, FACC{dagger},*

* Division of Cardiology, University of Kansas School of Medicine, Wichita, Kansas
{dagger} Division of Cardiology, Emory University School of Medicine, Atlanta, Georgia
{ddagger} Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia
§ Centers for Disease Control and Prevention, Atlanta, Georgia


Figure 1
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  		Figure 1 Pearson correlations between the markers of oxidative stress and high-sensitivity C-reactive protein (hs-CRP) and carotid intima-media thickness (IMT). (Top row, right) Eh GSH/GSSG; left: GSH; (bottom row, left) CySS; right: hs-CRP. CySS = cystine; Eh GSH/GSSG = glutathione redox state.

 

Figure 2
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  		Figure 2 Relationship between Eh GSH/GSSG tertiles and carotid IMT: unadjusted relationship between carotid IMT (mean ± SEM) and Eh GSH/GSSG tertiles (p = 0.005 for trend, and p = 0.004 highest vs. lowest EhGSH/GSSG tertiles, n = 38 in each group). Abbreviations as in Figure 1.

 

Figure 3
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  		Figure 3 Combined predictive value of Framingham risk score and Eh GSH/GSSG: subjects with higher levels of both oxidative stress and Framingham risk score had higher IMT (mean ± SEM) compared to subjects with lower levels of both markers (p < 0.001 highest vs. lowest group and p = 0.01 for trend). Abbreviations as in Figure 1.

 




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