A Comparison of the Clinical Impact of Bleeding Measured by Two Different Classifications Among Patients With Acute Coronary Syndromes
Sunil V. Rao, MD*,*,
Kristi O’Grady, MS*,
Karen S. Pieper, MS*,
Christopher B. Granger, MD, FACC*,
L. Kristin Newby, MD, MHS, FACC*,
Kenneth W. Mahaffey, MD, FACC*,
David J. Moliterno, MD, FACC ,
A. Michael Lincoff, MD, FACC ,
Paul W. Armstrong, MD, FACC ,
Frans Van de Werf, MD, FACC||,
Robert M. Califf, MD, FACC* and
Robert A. Harrington, MD, FACC*
* Duke Clinical Research Institute, Durham, North Carolina
University of Kentucky, Lexington, Kentucky
Cleveland Clinic Foundation, Cleveland, Ohio
University of Alberta, Edmonton, Alberta, Canada
|| Universitaire Ziekenhuizen Leuven, Leuven, Belgium.
View larger version (16K):
[in a new window]
|
Figure 1 (A) Adjusted hazard ratios of 30-day death or myocardial infarction (MI) by worsening Global Strategies for Opening Occluded Coronary Arteries (GUSTO) and Thrombolysis In Myocardial Infarction (TIMI) bleeding severity. Separate models constructed for each bleeding scale. Adjusted for age, gender, weight, site, diabetes mellitus, smoking status, prior angina, peripheral vascular disease, pre-randomization therapy, MI at enrollment, systolic blood pressure at randomization, diastolic blood pressure at randomization, heart rate at randomization, Killip class, and assigned treatment. (B) Adjusted hazard ratios for six-month death or MI by worsening GUSTO and TIMI bleeding severity. Separate models constructed for each bleeding definition. Separate models constructed for each scale. Adjusted for age, gender, weight, site, diabetes mellitus, smoking status, prior angina, peripheral vascular disease, pre-randomization therapy, MI at enrollment, systolic blood pressure at randomization, diastolic blood pressure at randomization, heart rate at randomization, Killip class, and assigned treatment.
|
|
View larger version (14K):
[in a new window]
|
Figure 2 (A) Hazard ratios of 30-day death or myocardial infarction (MI) by Global Strategies for Opening Occluded Coronary Arteries (GUSTO) and Thrombolysis In Myocardial Infarction (TIMI) bleeding severity after adjustment for blood transfusion. Separate models constructed for each scale. Adjusted for age, gender, weight, site, diabetes mellitus, smoking status, prior angina, peripheral vascular disease, pre-randomization therapy, MI at enrollment, systolic blood pressure at randomization, diastolic blood pressure at randomization, heart rate at randomization, Killip class, assigned treatment, and blood transfusion. (B) Hazard ratios of six-month death or MI by worsening GUSTO and TIMI bleeding severity after adjustment for blood transfusion. Separate models constructed for each scale. Adjusted for age, gender, weight, site, diabetes mellitus, smoking status, prior angina, peripheral vascular disease, pre-randomization therapy, MI at enrollment, systolic blood pressure at randomization, diastolic blood pressure at randomization, heart rate at randomization, Killip class, assigned treatment, and blood transfusion.
|
|
View larger version (13K):
[in a new window]
|
Figure 3 (A) Hazard ratios of 30-day death or myocardial infarction (MI) by worsening Global Strategies for Opening Occluded Coronary Arteries (GUSTO) and Thrombolysis In Myocardial Infarction (TIMI) bleeding severity after including both scales in the same model. Adjusted for age, gender, weight, site, diabetes mellitus, smoking status, prior angina, peripheral vascular disease, pre-randomization therapy, MI at enrollment, systolic blood pressure at randomization, diastolic blood pressure at randomization, heart rate at randomization, Killip class, assigned treatment, and blood transfusion. (B) Hazard ratios of six-month death or MI by worsening GUSTO and TIMI bleeding severity after including both scales in the same model. Adjusted for age, gender, weight, site, diabetes mellitus, smoking status, prior angina, peripheral vascular disease, pre-randomization therapy, MI at enrollment, systolic blood pressure at randomization, diastolic blood pressure at randomization, heart rate at randomization, Killip class, assigned treatment, and blood transfusion.
|
|
|
