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The Risk of Hemorrhage Among Patients With Warfarin-Associated Coagulopathy

David A. Garcia, MD^_*,2,_*, Susan Regan, PhD, Mark Crowther, MD^,3 and Elaine M. Hylek, MD, MPH^,1

^_* Department of Medicine, University of New Mexico, Albuquerque, New Mexico
Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Department of Medicine, General Internal Medicine Research Unit, Boston University School of Medicine, Boston Medical Center, Boston, Massachusetts.

View larger version (14K): [in a new window]   Figure 1 Box and whisker plot of the next consecutive international normalized ratio (INR) value obtained after the index INR, plotted by the number of days between the index and next INR date. The boxes delineate the interquartile range, extending from the 25th to the 75th percentile. The bar across the middle of the box represents the median. The whiskers reach to the most extreme value that is within 1.5 times the interquartile range beyond the box. Points more extreme than that are individually plotted. Patients for whom vitamin K use was documented and patients whose warfarin therapy was not interrupted have been excluded from this analysis.