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The Effect of Valsartan, Captopril, or Both on Atherosclerotic Events After Acute Myocardial Infarction

An Analysis of the Valsartan in Acute Myocardial Infarction Trial (VALIANT)

John McMurray, MD, FACC^_*,_*, Scott Solomon, MD, FACC, Karen Pieper, MS, Shelby Reed, PhD, Jean Rouleau, MD, FACC, Eric Velazquez, MD, Harvey White, DSc, FACC^||, Jonathan Howlett, MD^¶, Karl Swedberg, MD, PhD^#, Aldo Maggioni, MD^_**, Lars Køber, MD, PhD, Frans Van de Werf, MD, FACC, Rob Califf, MD, FACC and Marc Pfeffer, MD, PhD, FACC

^_* Department of Cardiology, Western Infirmary, Glasgow, Scotland
Cardiovascular Division, Brigham and Women’s Hospital, Boston, Massachusetts
Duke University Medical Center, Durham, North Carolina
The Montreal Heart Institute, Montreal, Canada
^|| Department of Cardiology, Green Lane Hospital, Auckland, New Zealand
^¶ QE 11 Heart Function and Transplantation Clinic, Dalhousie University, Halifax, Nova Scotia, Canada
^# Department of Medicine, Sahlgrenska University Hospital, Göteborg, Sweden
^_** ANMCO Research Center, Florence, Italy
Department of Cardiology University of Copenhagen, Copenhagen, Denmark
Leuven Coordinating Center, Leuven, Belgium

View larger version (42K): [in a new window]   Figure 1 Cumulative Kaplan-Meier event rates (fatal and non-fatal) in the three treatment groups in the Valsartan in Acute Myocardial Infarction Trial (VALIANT). The p values are for comparisons with captopril and are based on log-rank tests. Black line = captopril; blue line = valsartan; orange line = combination.

View larger version (20K): [in a new window]   Figure 2 Cumulative Kaplan-Meier event-free survival rates in the combination of treatment by statin groups in Valsartan in Acute Myocardial Infarction Trial (VALIANT). The p values are for interactions of statin with valsartan versus captopril and of statin with combination therapy versus captopril (from an adjusted Cox proportional hazards model). MI = myocardial infarction.