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Hypertension, Menopause, and Coronary Artery Disease Risk in the Women’s Ischemia Syndrome Evaluation (WISE) Study

Gretchen L. Gierach, MPH^_*, B. Delia Johnson, PhD^_*, C. Noel Bairey Merz, MD, FACC^,_*, Sheryl F. Kelsey, PhD^_*, Vera Bittner, MD, FACC, Marian B. Olson, MS^_*, Leslee J. Shaw, PhD, Sunil Mankad, MD, FACC^||, Carl J. Pepine, MD, FACC^¶, Steven E. Reis, MD, FACC^#, William J. Rogers, MD, FACC, Barry L. Sharaf, MD, FACC^_**, George Sopko, MD for the WISE Study Group

^_* Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania
Department of Medicine, Cedars-Sinai Research Institute, Cedars-Sinai Medical Center, and Department of Medicine, University of California School of Medicine, Los Angeles, California
Division of Cardiology, Department of Medicine, University of Alabama, Birmingham, Alabama
Atlanta Cardiovascular Research Institute, Atlanta, Georgia
^|| Division of Cardiology, Department of Medicine, Allegheny General Hospital, Pittsburgh, Pennsylvania
^¶ Division of Cardiology, Department of Medicine, University of Florida, Gainesville, Florida
^# Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
^_** Division of Cardiology, Rhode Island Hospital, Providence, Rhode Island
Division of Cardiology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland

View larger version (16K): [in a new window]   Figure 1 Increasing (A) systolic blood pressure (SBP, mm Hg) and (B) pulse pressure (PP, mm Hg) and odds of coronary artery disease (CAD) in premenopausal (PRE) and postmenopausal (POST) women. *CAD = angiographic coronary artery disease defined as 50% luminal diameter stenosis in 1 epicardial coronary artery.