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Impaired Coronary Vascular Reactivity and Functional Capacity in Women

Results From the NHLBI Women’s Ischemia Syndrome Evaluation (WISE) Study

Eileen Handberg, PhD^_*,_*, B. Delia Johnson, PhD, Christopher B. Arant, MD^_*, Timothy R. Wessel, MD^_*, Richard A. Kerensky, MD, FACC^_*, Gregory von Mering, MD^_*, Marian B. Olson, MS, Steven E. Reis, MD, Leslee Shaw, PhD, C. Noel Bairey Merz, MD, FACC^||, Barry L. Sharaf, MD, FACC^¶, George Sopko, MD^# and Carl J. Pepine, MD, MACC^_*

^_* Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, Florida
Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania
University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
Atlanta Cardiovascular Research Institute, Atlanta, Georgia
^|| Division of Cardiology, Department of Medicine, Cedars-Sinai Research Institute, Cedars-Sinai Medical Center, Los Angeles, California
^¶ Division of Cardiology, Rhode Island Hospital, Providence, Rhode Island
^# Division of Heart and Vascular Disease, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland

View larger version (56K): [in a new window]   Figure 1 Percentage of women with low, medium, and high Duke Activity Status Index (DASI) by coronary flow velocity (CFR). DASI tertiles: 0 to 9.8 (n = 63), 9.9 to 19.9 (n = 63), 20 to 58.2 (n = 62). CFVRado tertiles: 0.58 to 2.22 (n = 63), 2.23 to 2.69 (n = 65), 2.7 to 4.48 (n = 62). Open bars = low DASI; solid bars = medium DASI; ruled bars = high DASI.