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Increased Myocardial Fatty Acid Metabolism in Patients With Type 1 Diabetes Mellitus

Pilar Herrero, MS^_*, Linda R. Peterson, MD^,, Janet B. McGill, MD, Stanley Matthew, MD, Donna Lesniak, RN^_*, Carmen Dence, MS^_* and Robert J. Gropler, MD^_*,,_*

^_* Division of Radiological Sciences, Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri
Cardiovascular Division, Washington University School of Medicine, St. Louis, Missouri
Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri
Division of Endocrinology and Metabolism, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri

View larger version (24K): [in a new window]   Figure 1 Plasma insulin, glucose, lactate, and free fatty acid (FFA) levels during positron emission tomography imaging in both the non-diabetics (ND) and diabetic (DM) subjects. *p = 0.04, **p < 0.0001.

View larger version (27K): [in a new window]   Figure 2 Measurements of myocardial glucose extraction fraction (MGEF) and overall utilization (MGU) in both the non-diabetic (ND) and diabetic (DM) subjects. *p = 0.013, **p = 0.0008.

View larger version (24K): [in a new window]   Figure 3 Measurements of myocardial fatty acid extraction fraction (MFAEF), overall myocardial fatty acid utilization (MFAU), myocardial fatty acid oxidation (MFAO), and myocardial fatty acid fractional oxidation (%MFAO) in both the non-diabetic (ND) and diabetic (DM) subjects. *p = 0.0004, **p = 0.0002, p = 0.04.

View larger version (22K): [in a new window]   Figure 4 Correlation of fractional myocardial fatty acid oxidation (%MFAO) and plasma fatty acid levels in both non-diabetic and diabetic subjects. DM = diabetes mellitus; NV = normal volunteers.

View larger version (16K): [in a new window]   Figure 5 Correlation of fractional myocardial fatty acid oxidation (%MFAO) and duration of diabetes in the diabetic subjects. DM = diabetes mellitus.