Relationship Between Renal Function and Plasma Brain Natriuretic Peptide in Patients With Heart Failure
Takayoshi Tsutamoto, MD*,
Atsuyuki Wada, MD,
Hiroshi Sakai, MD,
Chitose Ishikawa, MD,
Toshinari Tanaka, MD,
Masaru Hayashi, MD,
Masanori Fujii, MD,
Takashi Yamamoto, MD,
Tomohiro Dohke, MD,
Masato Ohnishi, MD,
Hiroyuki Takashima, MD,
Masahiko Kinoshita, MD and
Minoru Horie, MD
Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Otsu, Japan
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Figure 1 Relationship between the estimated glomerular filtration rate (eGFR) and the plasma log brain natriuretic peptide (BNP) secretion and the log BNP in the aortic root (AO). CS = coronary sinus.
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Figure 2 Comparisons between hemodynamic parameters and brain natriuretic peptide (BNP). The box defines the interquartile range with the median indicated by the crossbar. Group 1 = patients with an estimated glomerular filtration rate (eGFR)  60 ml/min; group 2 = patients with an eGFR <60 ml/min. AO = aortic root; CS = coronary sinus; LVEDP = left ventricular end-diastolic pressure; LVEF = left ventricular ejection fraction.
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Figure 3 (A) Relationship between the log brain natriuretic peptide (BNP) secretion and hemodynamic parameters. (B) Relationship between log BNP in the aortic root (AO) and hemodynamic parameters. Open circles = group 1 patients; cross marks = group 2 patients; solid lines = patients in group 1; dotted lines = patients in group 2. There were significant correlations between left ventricular end-diastolic pressure (LVEDP), left ventricular ejection fraction (LVEF), and the transcardiac increase in BNP in both groups with the same regression line (A). The regression line between the LVEDP, LVEF, and log BNP in the AO of group 2 showed a significant shift upward compared with that of group 1 (B). CS = coronary sinus.
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Figure 4 (A) Interaction between New York Heart Association (NYHA) functional class and renal function on brain natriuretic peptide (BNP) secretion (transcardiac increase of BNP). (B) Interaction between NYHA functional class and renal function on plasma BNP. Median values and patients’ numbers are shown. Other abbreviations as in Figure 3.
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