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Plasma Nitroso Compounds Are Decreased in Patients With Endothelial Dysfunction

Christian Heiss, MD^_*, Thomas Lauer, MD, André Dejam, MD^_*, Petra Kleinbongard, PhD^_*, Sandra Hamada, MS^_*, Tienush Rassaf, MD^_*, Simone Matern, BS^_*, Martin Feelisch, PhD and Malte Kelm, MD^_*,_*

^_* Department of Cardiology, Pneumology, and Vascular Medicine, RWTH Aachen, Aachen, Germany
Department of Cardiology, Pneumology, and Angiology, Heinrich-Heine University, Duesseldorf, Germany
Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts

View larger version (20K): [in a new window]   Figure 1 Endothelial function and plasma nitric oxide species are decreased in individuals with increasing numbers of cardiovascular risk factors. (A) Flow-mediated dilation (FMD) and (B) percentage of FMD compared to glycerol trinitrate (GTN)-induced dilation of brachial artery (FMD/GTN ratio) are significantly lower in individuals with cardiovascular risk factors. (C) Nitros(yl)ated species (RXNO) in plasma, representing the circulating pool of bioactive nitric oxide, are also significantly attenuated with increasing numbers of risk factors. Columns = mean values; error bars = SE. P values are Bonferroni-corrected for 10 pairwise comparisons.

View larger version (35K): [in a new window]   Figure 2 Vascular endothelial function correlates with circulating nitric oxide (NO) pool. Endothelial function, measured as NO-dependent flow-mediated dilation of the brachial artery, correlates with the concentration of circulating nitroso/nitrosyl species (RXNO) in plasma (r = 0.41, p < 0.001). Circles = individual values; filling = number of major cardiovascular risk factors (RF).