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Microvolt T-Wave Alternans and the Risk of Death or Sustained Ventricular Arrhythmias in Patients With Left Ventricular Dysfunction

Daniel M. Bloomfield, MD, FACC^_*,_*, J. Thomas Bigger, MD, FACC^_*, Richard C. Steinman, AB^_*, Pearila B. Namerow, PhD^_*, Michael K. Parides, PhD^_*, Anne B. Curtis, MD, FACC, Elizabeth S. Kaufman, MD, FACC, Jorge M. Davidenko, MD, FACC, Timothy S. Shinn, MD, FACC^|| and John M. Fontaine, MD, FACC^¶

^_* Columbia University Medical Center, New York, New York
Department of Medicine, University of South Florida, Tampa, Florida
MetroHealth, Case Western Reserve University, Cleveland, Ohio
New York Heart Center, Syracuse, New York
^|| Michigan Heart PC, Ypsilanti, Michigan
^¶ Drexel University College of Medicine, Philadelphia, Pennsylvania

View larger version (16K): [in a new window]   Figure 1 Kaplan-Meier mortality curves for patients with normal versus abnormal microvolt T-wave alternans (MTWA) test results. In two years of follow-up, only 4 events occurred in the 189 patients with a normal MTWA test; 47 events occurred in the group with an abnormal MTWA test. Abnormal MTWA tests comprise positive tests (n = 162, two-year event rate 12.3%) and indeterminate tests (n = 198, two-year event rate 17.5%).