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J Am Coll Cardiol, 2006; 47:405-410, doi:10.1016/j.jacc.2005.08.064 (Published online 20 December 2005).
© 2006 by the American College of Cardiology Foundation
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Caffeine Decreases Exercise-Induced Myocardial Flow Reserve

Mehdi Namdar, MD*, Pascal Koepfli, MD*, Renate Grathwohl, MD*, Patrick T. Siegrist, MD*, Michael Klainguti, MD*, Tiziano Schepis, MD*, Raphael Delaloye, MD*, Christophe A. Wyss, MD*, Samuel P. Fleischmann, MD*, Oliver Gaemperli, MD* and Philipp A. Kaufmann, MD*,{dagger},a,*

* Cardiovascular Center, Nuclear Cardiology, University Hospital, Zurich, Switzerland.
{dagger} Center for Integrative Human Physiology (CIHP), University of Zurich, Zurich, Switzerland.



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  		Figure 1 Individual values for myocardial blood flow (MBF) at rest and after exercise before and after caffeine consumption.

 


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  		Figure 2 Changes in myocardial blood flow (MBF) induced by caffeine. After caffeine consumption, resting MBF increased at hypoxia but not at normoxia, whereas exercise-induced hyperemic flow response was decreased in both groups. Caffeine blunted the hyperemic flow significantly more pronounced at altitude than at normoxia. Open bars = normoxia; solid bars = hypoxia. *p < 0.05 vs. baseline.

 


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  		Figure 3 Individual myocardial flow reserve (MFR) values before and after caffeine. Caffeine decreased MFR in both groups.

 




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