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Long-Term Caloric Restriction Ameliorates the Decline in Diastolic Function in Humans

Timothy E. Meyer, PhD^_*,, Sándor J. Kovács, PhD, MD, Ali A. Ehsani, MD^_*,, Samuel Klein, MD^_*, John O. Holloszy, MD^_* and Luigi Fontana, MD, PhD^_*,,_*

^_* Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St. Louis, Missouri
Cardiovascular Biophysics Laboratory, Washington University School of Medicine, St. Louis, Missouri
Division of Human Nutrition, Istituto Superiore di Sanità, Rome, Italy

View larger version (36K): [in a new window]   Figure 1 The model-based image processing (MBIP) method of quantitative diastolic function assessment using the Doppler image as input. MSE = mean square error; MVE = maximum velocity envelope; PDF = parameterized diastolic filling.

View larger version (23K): [in a new window]   Figure 2 Doppler mitral inflow patterns in a typical young individual (left panel), age-matched comparison subject (middle panel), and representative caloric restriction (CR) subject (right panel). WD = Western diet.