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Prolonged QTc Interval and Risk of Sudden Cardiac Death in a Population of Older Adults

Sabine M.J.M. Straus, MD, PhD^_*,,, Jan A. Kors, PhD, Marie L. De Bruin, PhD, Cornelis S. van der Hooft, MD^,||, Albert Hofman, MD, PhD^_*, Jan Heeringa, MD^_*, Jaap W. Deckers, MD, PhD^_*, J. Herre Kingma, MD, PhD^||,¶, Miriam C.J.M. Sturkenboom, PhD^_*,, Bruno H. Ch. Stricker, PhD^_*,||,_* and Jacqueline C.M. Witteman, PhD^_*

^_* Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, the Netherlands
Department of Medical Informatics, Erasmus Medical Center, Rotterdam, the Netherlands
Medicines Evaluation Board, the Hague, the Netherlands
Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht, the Netherlands
^|| Inspectorate for Healthcare, the Hague, the Netherlands
^¶ Department of Clinical Pharmacology, University of Groningen, Groningen, the Netherlands.

View larger version (25K): [in a new window]   Figure 1 Kaplan-Meier log survival plot of heart rate corrected QT (QTc) interval prolongation and sudden cardiac death.

View larger version (10K): [in a new window]   Figure 2 Risk of sudden cardiac death (SCD) at different heart rate corrected QT (QTc) interval cutoff points. *Adjusted for age, gender, body mass index, cholesterol/high-density lipoprotein ratio, smoking, hypertension, diabetes, myocardial infarction, and heart rate. CI = confidence interval; HR = hazard ratio.