This Article Abstract Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (10) Citing Articles via Google Scholar Google Scholar Articles by Hanninen, S. A. Articles by Keith, M. E. Search for Related Content PubMed PubMed Citation Articles by Hanninen, S. A. Articles by Keith, M. E.

The Prevalence of Thiamin Deficiency in Hospitalized Patients With Congestive Heart Failure

Stacy A. Hanninen, RD, MSc^_*,, Pauline B. Darling, PhD, RD^,, Michael J. Sole, MD, FRCPC, FACC^||,_**, Aiala Barr, PhD^¶ and Mary E. Keith, PhD^,#,_*

^_* Heart and Vascular Program, St. Michael’s Hospital, Toronto, Ontario, Canada
Department of Nutrition, St. Michael’s Hospital, Toronto, Ontario, Canada
Division of Cardiovascular and Thoracic Surgery, St. Michael’s Hospital, Toronto, Ontario, Canada
Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
^|| Heart and Stroke/Richard Lewar Centre of Excellence, University of Toronto, Toronto, Ontario, Canada
^¶ Department of Public Health, University of Toronto, Toronto, Ontario, Canada
^# Department of Surgery, University of Toronto, Toronto, Ontario, Canada
^_** Division of Cardiology, University Health Network, Toronto, Ontario, Canada.

View larger version (36K): [in a new window]   Figure 1 The distribution of erythrocyte thiamin pyrophosphate (TPP) in congestive heart failure (CHF) patients by grade of left ventricular function. Grade 1 or 2 = ejection fraction (EF) >35%, grade 3 or 4 = EF <35%. The dashed line is drawn at an erythrocyte TPP of 78 ng/ml packed red blood cells (RBCs). Congestive heart failure patients with a TPP below this cut point were considered thiamin deficient (TD).

View larger version (14K): [in a new window]   Figure 2 The distribution of erythrocyte TPP in healthy control patients. The dashed line is drawn at TPP of 78 ng/ml packed RBCs. Controls with TPP values below this cut point were considered TD. Abbreviations as in Figure 1.

View larger version (28K): [in a new window]   Figure 3 The distribution of erythrocyte TPP in CHF patients according to use of thiamin-containing multivitamins. The dashed line is drawn at an erythrocyte TPP of 78 ng/ml packed RBCs. Congestive heart failure patients with a TPP below this cut point were considered TD. Abbreviations as in Figure 1.

View larger version (39K): [in a new window]   Figure 4 The distribution of urinary losses of thiamin per gram of creatinine by left ventricular (LV) function grade. Grade 1 or 2 = EF >35%, grade 3 or 4 = EF <35%. The dashed line indicates urine thiamin loss of 66 µg/g creatinine, the level above which has been proposed to represent normal urinary thiamin excretion (2).

View larger version (20K): [in a new window]   Figure 5 The relationship between estimated daily intake of thiamin (mg) and total urine thiamin (µg/day).