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J Am Coll Cardiol, 2006; 47:2374-2379, doi:10.1016/j.jacc.2005.09.080 (Published online 25 May 2006).
© 2006 by the American College of Cardiology Foundation
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Correlates of Bleeding Events Among Moderate- to High-Risk Patients Undergoing Percutaneous Coronary Intervention and Treated With Eptifibatide

Observations From the PROTECT–TIMI-30 Trial

Ajay J. Kirtane, MD, SM*, Gregory Piazza, MD*, Sabina A. Murphy, MPH{dagger}, Daniela Budiu, MD{dagger}, David A. Morrow, MD, MPH, FACC{dagger}, David J. Cohen, MD, MSc*,1, Eric Peterson, MD, MPH, FACC{ddagger},2, Nasser Lakkis, MD, FACC§, Howard C. Herrmann, MD, FACC||,3, Theresa M. Palabrica, MD,4, C. Michael Gibson, MS, MD, FACC*,{dagger},5,* for the TIMI Study Group

* Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center
{dagger} Cardiovascular Division, Department of Medicine, Brigham & Women’s Hospital, Harvard Medical School, Boston, Massachusetts
{ddagger} Duke Clinical Research Institute, Durham, North Carolina
§ Ben Taub General Hospital, Houston, Texas
|| University of Pennsylvania Medical Center, Philadelphia, Pennsylvania
Millennium Pharmaceuticals, Cambridge, Massachusetts


Figure 1
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  		Figure 1 Relation of age and bleeding.

 

Figure 2
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  		Figure 2 Relation of creatinine clearance (CrCl) and bleeding. IQ = interquartile range.

 

Figure 3
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  		Figure 3 Cumulative distribution function of duration of eptifibatide infusion in patients (pts) with bleeding. IQ = interquartile range.

 

Figure 4
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  		Figure 4 Relation of dose adjustment of eptifibatide infusion to bleeding. CrCl = creatinine clearance.

 




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Copyright © 2006 by the American College of Cardiology Foundation.