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Serum Tenascin-C Might Be a Novel Predictor of Left Ventricular Remodeling and Prognosis After Acute Myocardial Infarction

Akira Sato, MD^_*, Kazutaka Aonuma, MD, Kyoko Imanaka-Yoshida, MD^,_*, Toshimichi Yoshida, MD, Mitsuaki Isobe, MD, Daisuke Kawase^||, Noriaki Kinoshita, PhD^||, Yoshio Yazaki, MD^¶ and Michiaki Hiroe, MD^#

^_* Department of Cardiology, Yokosuka Kyosai Hospital, Yokosuka, Japan
Department of Cardiology, University of Tsukuba Graduate School of Comprehensive Human Science, Tsukuba, Japan
Departments of Pathology and Matrix Biology, Mie University Graduate School of Medicine, Tsu, Japan
Department of Cardiovascular Medicine, Tokyo Medical and Dental Postgraduate School of Medicine, Tokyo, Japan
^|| IBL Co., Gunma, Japan
^¶ National Hospital Organization, Tokyo, Japan
^# Department of Nephrology and Cardiology, International Medical Center of Japan, Tokyo, Japan

View larger version (100K): [in a new window]   Figure 1 Representative microscopic images of tenascin-C expression in autopsied human myocardia from a normal case (A, D, G), an acute myocardial infarction (AMI) patient 36 h after myocardial infarction (B, E, H), and an old myocardial infarction (OMI) patient (C, F, I). (A, B, C) H & E staining; (D, E, F) immunolabeling with antibody clones 4F10TT and (G, H, I) 6C6MS. Positive immunostainings with the two monoclonal antibodies were observed in the infarcted myocardial lesion of the AMI patients. Bar = 100 µm.

View larger version (22K): [in a new window]   Figure 2 Comparisons of serum tenascin-C (TN-C) levels between acute myocardial infarction (AMI), old myocardial infarction (OMI), and control cases. n.s. = not significant.

View larger version (18K): [in a new window]   Figure 3 Serial changes in serum tenascin-C (TN-C) and creatine kinase (CK)-MB levels in patients with acute myocardial infarction (AMI). Values represent the mean and standard error. Serum TN-C levels were elevated on admission, peaked at day 5, and then gradually decreased (A). In contrast, CK-MB levels peaked within 12 h and then rapidly decreased (B).